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Changes of circulating anti-A/B-antibody titers during the preparation period and after AB0-incompatible living donor kidney transplantation
- Source :
- Трансплантология (Москва), Vol 0, Iss 2-3, Pp 48-53 (2018)
- Publication Year :
- 2018
- Publisher :
- N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department, 2018.
-
Abstract
- Several protocols have been developed to overcome the blood group barrier in renal transplantation. In the evolution of these protocols, one of the latest steps was the combination of anti-CD20 treatment with antigen-specific immunoadsorption (IA) and intravenous immunoglobulin (IvIg). This protocol has been widespread used for AB0-incompatible transplantation in Europe. We report our first experience of five successful AB0-incompatible kidney transplantation using anti-CD20 + IA + IvIg pretransplant conditioning protocol and tacrolimus + MMF + steroids as maintenance immunosuppression. Initial anti-A/B-antidody titers were 1:16 to 1:1024. The transplantation could be performed in all cases and the grafts showed primary function.
Details
- Language :
- English, Russian
- ISSN :
- 20740506 and 25420909
- Issue :
- 2-3
- Database :
- Directory of Open Access Journals
- Journal :
- Трансплантология (Москва)
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.02807716605c4603aecfbdea427f1450
- Document Type :
- article
- Full Text :
- https://doi.org/10.23873/2074-0506-2011-0-2-3-48-53