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Study of subchronic oral toxicity of Altric-Extra drug in laboratory animals

Authors :
V. V. Golovin
S. V. Abramov
A. V. Balyshev
E. V. Lagereva
Source :
Российский паразитологический журнал, Vol 17, Iss 4, Pp 510-520 (2023)
Publication Year :
2023
Publisher :
Federal Scientific Centre VIEV, 2023.

Abstract

The purpose of the research is to determine main toxicological parameters in repeated intragastric administration of Altric-Extra for veterinary use to laboratory outbred rats.Materials and methods. White outbred rats were used as a test system in the study. The experiment used clinical, toxicological, biochemical and morphological research methods.Results and discussion. Altric-Extra doses of 325 and 650 mg/kg were toxic for the laboratory animals. When administered daily intragastrically to the rats in the above doses, the drug had a negative effect on the functional status of the hemopoietic organs, and excretory and digestive systems. The main target organ for this drug is the thymus. Functional disorders in the above organs and systems are irreversible as evidenced by the post-mortem examination, general blood analysis, and biochemical blood test obtained 10 days after the drug administration was completed.

Details

Language :
Russian
ISSN :
19988435 and 25417843
Volume :
17
Issue :
4
Database :
Directory of Open Access Journals
Journal :
Российский паразитологический журнал
Publication Type :
Academic Journal
Accession number :
edsdoj.0262aabfd23c4d3481dd99a0dc853295
Document Type :
article
Full Text :
https://doi.org/10.31016/1998-8435-2023-17-4-510-520