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Toward the Development of Plasmonic Biosensors to Realize Point-of-Care Tests for the Detection of Viruses and Bacteria

Authors :
Francesco Arcadio
Ines Tavoletta
Chiara Marzano
Luca Pasquale Renzullo
Nunzio Cennamo
Luigi Zeni
Source :
Engineering Proceedings, Vol 56, Iss 1, p 113 (2023)
Publication Year :
2023
Publisher :
MDPI AG, 2023.

Abstract

Optical fiber biosensors can be used to develop point-of-care tests (POCTs) for detecting viruses and bacteria in several matrices. In particular, the surface plasmon resonance (SPR) and localized SPR phenomena (LSPR) can be excited by exploiting low-cost and small-size optical fiber chips. Generally, SPR or LSPR sensors are realized using several kinds of modified optical fibers (silica, plastic, or specialty) or by exploiting other optical waveguides (e.g., slab, spoon-shaped waveguides, etc.). More specifically, optical fiber sensors can be classified as intrinsic or extrinsic. In the “optical fiber intrinsic sensors”, the sensing area is realized in the optical fiber directly, such as in the case of plasmonic platforms based on D-shaped plastic optical fibers (POFs), tapered optical fibers, U-bend POFs, or light-diffusing fibers (LDFs). By contrast, when an optical fiber is used as a mere waveguide allowing for the launch of light to the sensing region and its collection, it is defined as an extrinsic optical fiber sensor, like in the case of the plasmonic sensors realized by Cennamo et al. using POFs combined with spoon-shaped waveguides, 3D-printed platforms, bacterial cellulose waveguides, nanogratings, and InkJet-printed chips. To realize optical biosensor chips for the detection of viruses and bacteria, both intrinsic and extrinsic plasmonic POF sensors can be efficiently combined with receptors specific for membrane proteins, either biological (e.g., antibodies, aptamers, enzymes, etc.) or synthetic (e.g., molecularly imprinted polymers), to build groundbreaking POCTs.

Details

Language :
English
ISSN :
26734591
Volume :
56
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Engineering Proceedings
Publication Type :
Academic Journal
Accession number :
edsdoj.021dfc501d34ba69ca5d798a62ecc87
Document Type :
article
Full Text :
https://doi.org/10.3390/ASEC2023-15277