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Normalizing and denoising protein expression data from droplet-based single cell profiling

Authors :
Matthew P. Mulè
Andrew J. Martins
John S. Tsang
Source :
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Publication Year :
2022
Publisher :
Nature Portfolio, 2022.

Abstract

Current single cell protein expression profiling approaches come with substantial measurement noise. Here the authors discover the sources of this noise and develop a denoising algorithm that improves data quality and downstream applications.

Subjects

Subjects :
Science

Details

Language :
English
ISSN :
20411723
Volume :
13
Issue :
1
Database :
Directory of Open Access Journals
Journal :
Nature Communications
Publication Type :
Academic Journal
Accession number :
edsdoj.01e0db9ea26e48418ff9d13820efbeb6
Document Type :
article
Full Text :
https://doi.org/10.1038/s41467-022-29356-8