Back to Search
Start Over
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- SIRT7 is a member of sirtuin family proteins that are described as NAD+-dependent class III histone deacetylases. Here, the authors show that SIRT7 is histone desuccinylase catalysing H3K122 desuccinylation, thereby promoting chromatin condensation and repair of DNA double strand breaks.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.01d2d2142bd449bf920ece34e4a0cc1c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/ncomms12235