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Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) study protocol: a prospective observational cohort study of reproductive-aged women living with HIV

Authors :
Jessica Lee
Kathleen M Powis
Alejandra Martinez
Jennifer Green
Paige L Williams
Cristina Hernández
Lisa B Haddad
Anna-Barbara Moscicki
Lynn M Yee
Kunjal Patel
Deborah Kacanek
Suzanne Siminski
Mariam Davtyan
Tzy-Jyun Yao
Denise L Jacobson
Tamarra James-Todd
Ellen G Chadwick
Emily A Barr
Claire A Berman
Alex DiPerna
Amanda Flores
Laurie Hyzy
Jennifer Jao
Anisa Khadraoui
Kathleen M Malee
Lisa-Gaye Robinson
Liz Salomon
Kimbrae Sanders
Renee A Smith
Tracy Wolbach
Lela Lartey
Kathleen Malee
Mary Paul
Lynnette Harris
Murli Purswani
Martha Cavallo
Mahoobullah Mirza Baig
Alma Villegas-Schwalenberg
Kierra Archer
Alan Bernegger
Patricia Garvie
Katherine Knapp
Chloe Burkhead
Gheri Terry
Megan Wilkins
Margarita Silio
Dornese Jones
Medea Gabriel
Patricia Sirois
Cecelia Hutto
Paige Hickman
Dan Marullo
Elizabeth McFarland
Carrie Chambers
Robin McEvoy
Mobeen Rathore
Saniyyah Mahmoudi
Staci Routman
Gwendolyn Scott
Lorena Bracho
Anai Cuadra
Zoe M. Rodriguez
Lizmarie Torres
Nydia Scalley
Toniette Frederick
Guadalupe Morales Avendano
Source :
BMJ Open, Vol 14, Iss 7 (2024)
Publication Year :
2024
Publisher :
BMJ Publishing Group, 2024.

Abstract

Introduction Over 265 000 women are living with HIV in the USA, but limited research has investigated the physical, mental and behavioural health outcomes among women living with HIV of reproductive age. Health status during the reproductive years before, during and after pregnancy affects pregnancy outcomes and long-term health. Understanding health outcomes among women living with HIV of reproductive age is of substantial public health importance, regardless of whether they experience pregnancy. The Health Outcomes around Pregnancy and Exposure to HIV/Antiretrovirals (HOPE) study is a prospective observational cohort study designed to investigate physical and mental health outcomes of young women living with HIV as they age, including HIV disease course, engagement in care, reproductive health and choices and cardiometabolic health. We describe the HOPE study design, and characteristics of the first 437 participants enrolled as of 1 January 2024.Methods and analysis The HOPE study seeks to enrol and follow 1630 women living with HIV of reproductive age, including those with perinatally-acquired HIV, at 12 clinical sites across 9 US states and Puerto Rico. HOPE studies multilevel dynamic determinants influencing physical, mental and social well-being and behaviours of women living with HIV across the reproductive life course (preconception, pregnancy, post partum, not or never-pregnant), informed by the socioecological model. Key research areas include the clinical course of HIV, relationship of HIV and antiretroviral medications to reproductive health, pregnancy outcomes and comorbidities and the influence of racism and social determinants of health. HOPE began enrolling in April 2022.Ethics and dissemination The HOPE study received approval from the Harvard Longwood Campus Institutional Review Board, the single institutional review board of record for all HOPE sites. Results will be disseminated through conference presentations, peer-reviewed journals and lay summaries.

Subjects

Subjects :
Medicine

Details

Language :
English
ISSN :
20240848 and 20446055
Volume :
14
Issue :
7
Database :
Directory of Open Access Journals
Journal :
BMJ Open
Publication Type :
Academic Journal
Accession number :
edsdoj.014d967489947ba9e35b6a7aff1767e
Document Type :
article
Full Text :
https://doi.org/10.1136/bmjopen-2024-084835