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The use of regorafenib in patients with disseminated gastrointestinal stromal tumours. A review of the literature. A clinical case
- Source :
- Медицинский совет, Vol 0, Iss 10, Pp 12-16 (2018)
- Publication Year :
- 2018
- Publisher :
- Remedium Group LLC, 2018.
-
Abstract
- The survival of patients even with disseminated disease reached 7–8 years after introduction of imatinib and sunitinib for the treatment of gastrointestinal stromal tumours (GIST) into everyday clinical practice. These drugs efficacy is largely determined by the presence and any mutations of C-KIT and PDGFR genes. It was established that new mutations appear in most tumours against the background of tyrosine kinase inhibitors therapy, which causes the development of secondary resistance and the progression of the disease in most cases. The search for opportunities to overcome the newly developed or initially existing resistance caused by different gene mutations continues to be of vital importance. One of such drugs is regorafenib, which has demonstrated antitumour activity against progression on imatinib and/or sunitinib. The paper reviews the studies of the efficacy of regoraphanib in patients with disseminated GIST, taking into account the presence and any mutations of C-KIT and PDGFR genes, and presents a description of their own clinical case of prolonged use of the drug in a patient who have received earlier both imatinib and sunitinib.
Details
- Language :
- Russian
- ISSN :
- 2079701X and 26585790
- Issue :
- 10
- Database :
- Directory of Open Access Journals
- Journal :
- Медицинский совет
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.00cf503fcd4e4855be5b85746597314c
- Document Type :
- article
- Full Text :
- https://doi.org/10.21518/2079-701X-2018-10-12-16