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Neutrophil-Lymphocyte Ratio as an Independent Predictor of Survival in Pulmonary Arterial Hypertension: An Exploratory Study
- Source :
- CJC Open, Vol 4, Iss 4, Pp 357-363 (2022)
- Publication Year :
- 2022
- Publisher :
- Elsevier, 2022.
-
Abstract
- Background: The blood neutrophil-to-lymphocyte ratio (NLR) has recently emerged as a powerful predictor of adverse outcomes in some cardiovascular and lung diseases. Pulmonary arterial hypertension (PAH) is a lethal vasculopathy associated with increased inflammation. Although PAH exhibits a higher prevalence among women, men have a poorer prognosis. We investigated the NLR as an independent predictor of transplant-free survival in PAH. Methods: We performed a retrospective analysis of 78 PAH patients from the Quebec PAHBiobank (71% female). We used univariate and multivariate (adjusted for age, sex, renal function, and disease severity) Cox regression analyses to assess the relationship between the NLR and transplant-free survival, in the whole sample, and according to sex. The NLR was categorized as high (≥ 4.8) or low (
- Subjects :
- Diseases of the circulatory (Cardiovascular) system
RC666-701
Subjects
Details
- Language :
- English
- ISSN :
- 2589790X
- Volume :
- 4
- Issue :
- 4
- Database :
- Directory of Open Access Journals
- Journal :
- CJC Open
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.00c4f875c51f44cfb5f13afcb6c53fb1
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.cjco.2021.11.010