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External induction and stabilization of brain oscillations in the human

External induction and stabilization of brain oscillations in the human

Authors :
Tiam Hosseinian
Fatemeh Yavari
Maria Chiara Biagi
Min-Fang Kuo
Giulio Ruffini
Michael A. Nitsche
Asif Jamil
Source :
Brain Stimulation, Vol 14, Iss 3, Pp 579-587 (2021)
Publication Year :
2021
Publisher :
Elsevier, 2021.

Abstract

Background: Neural oscillations in the cerebral cortex are associated with a range of cognitive processes and neuropsychiatric disorders. However, non-invasively modulating oscillatory activity remains technically challenging, due to limited strength, duration, or non-synchronization of stimulation waveforms with endogenous rhythms. Objective: We hypothesized that applying controllable phase-synchronized repetitive transcranial magnetic stimulation pulses (rTMS) with alternating currents (tACS) may induce and stabilize neuro-oscillatory resting-state activity at targeted frequencies. Methods: Using a novel circuit to precisely synchronize rTMS pulses with phase of tACS, we empirically tested whether combined, 10-Hz prefrontal bilateral stimulation could induce and stabilize 10-Hz oscillations in the bilateral prefrontal cortex (PFC). 25 healthy participants took part in a repeated-measures design. Whole-brain resting-state EEG in eyes-open (EO) and eyes-closed (EC) was recorded before (baseline), immediately (1-min), and 15- and 30-min after stimulation. Bilateral, phase-synchronized rTMS aligned to the positive tACS peak was compared with rTMS at tACS trough, with bilateral tACS or rTMS on its own, and to sham. Results: 10-Hz resting-state PFC power increased significantly with peak-synchronized rTMS + tACS (EO: 44.64%, EC: 46.30%, p

Details

Language :
English
ISSN :
1935861X
Volume :
14
Issue :
3
Database :
Directory of Open Access Journals
Journal :
Brain Stimulation
Publication Type :
Academic Journal
Accession number :
edsdoj.0095b61eafe5443d9d015148b33a4d7f
Document Type :
article
Full Text :
https://doi.org/10.1016/j.brs.2021.03.011