Back to Search
Start Over
Non-Coding RNAs: Strategy for Viruses’ Offensive
- Source :
- Non-Coding RNA, Vol 6, Iss 3, p 38 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI AG, 2020.
-
Abstract
- The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle.
- Subjects :
- immune evasion
miRNA mimicry
viral circRNA
viral non-coding RNA
Genetics
QH426-470
Subjects
Details
- Language :
- English
- ISSN :
- 2311553X
- Volume :
- 6
- Issue :
- 3
- Database :
- Directory of Open Access Journals
- Journal :
- Non-Coding RNA
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.008f70b34244dc8e1f90c0533e1395
- Document Type :
- article
- Full Text :
- https://doi.org/10.3390/ncrna6030038