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Chemokine (C–C motif) receptor 2 is associated with the pathological grade and inflammatory response in IgAN children

Authors :
Yanjie Shen
Zhiqing Zhu
Rui Wang
Lili Yan
Shuaichen Sun
Ling Lu
Zhenhua Ren
Qin Zhang
Source :
BMC Nephrology, Vol 23, Iss 1, Pp 1-10 (2022)
Publication Year :
2022
Publisher :
BMC, 2022.

Abstract

Abstract Background Chemokine (C–C motif) receptor 2 (CCR2) is involved in important physiological and pathological processes, such as inflammation and autoimmune diseases. Abnormal immune and inflammatory responses play a critical role in the development and progression of IgA nephritis (IgAN). However, the role of CCR2 in IgAN is unknown. Methods Fifteen IgAN children who were diagnosed by kidney biopsy provided kidney biopsy tissue, blood and urine samples, and age-matched healthy control subjects (blood donators n = 12; tissue donators n = 8) were included. Immunohistochemical analysis was used to detect the expression of CCR2, MCP-1, IL-6, IL-17, and TNF-α in the kidney tissues. Relative optical density (OD) was calculated by Image J software, and the correlation between CCR2 expression and pathological grade in IgAN children was analyzed. Results The expression of CCR2 significantly increased in mesangial cells of children with IgAN compared to that in control group (P

Details

Language :
English
ISSN :
14712369
Volume :
23
Issue :
1
Database :
Directory of Open Access Journals
Journal :
BMC Nephrology
Publication Type :
Academic Journal
Accession number :
edsdoj.007766f5cdb042bc85469e7bf4b1b811
Document Type :
article
Full Text :
https://doi.org/10.1186/s12882-022-02839-y