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HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway
- Source :
- Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
- Publication Year :
- 2021
- Publisher :
- Nature Portfolio, 2021.
-
Abstract
- Resistance to HER2 inhibition in HER2- amplified breast cancer is common in the metastatic setting and the underlying molecular mechanisms remain unknown. Here, the authors, perform genomic profiling of 733 HER2-amplified breast cancers and propose genetic activation of MAPK as a resistance mechanism.
- Subjects :
- Science
Subjects
Details
- Language :
- English
- ISSN :
- 20411723 and 44044992
- Volume :
- 12
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Nature Communications
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.0069fe3f63d440449928bce36543115c
- Document Type :
- article
- Full Text :
- https://doi.org/10.1038/s41467-021-27093-y