Back to Search
Start Over
Tetrahydroquinoxalines induce a lethal evisceration phenotype in Haemonchus contortus in vitro
- Source :
- International Journal for Parasitology: Drugs and Drug Resistance, Vol 9, Iss , Pp 59-71 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- In the present study, the anthelmintic activity of a human tyrosine kinase inhibitor, AG-1295, and 14 related tetrahydroquinoxaline analogues against Haemonchus contortus was explored. These compounds were screened against parasitic larvae - exsheathed third-stage (xL3) and fourth-stage (L4) - using a whole-organism screening assay. All compounds were shown to have inhibitory effects on larval motility, development and growth, and induced evisceration through the excretory pore in xL3s. The estimated IC50 values ranged from 3.5 to 52.0 μM for inhibition of larval motility or development. Cytotoxicity IC50 against human MCF10A cells was generally higher than 50 μM. Microscopic studies revealed that this eviscerated (Evi) phenotype occurs rapidly (
- Subjects :
- Infectious and parasitic diseases
RC109-216
Subjects
Details
- Language :
- English
- ISSN :
- 22113207
- Volume :
- 9
- Issue :
- 59-71
- Database :
- Directory of Open Access Journals
- Journal :
- International Journal for Parasitology: Drugs and Drug Resistance
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.004597e54aa1a78f4bf273595773
- Document Type :
- article
- Full Text :
- https://doi.org/10.1016/j.ijpddr.2018.12.007