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Genetic and physical mapping of autosomal dominant polycystic kidney disease

Authors :
Pound, Susan Elizabeth
Publication Year :
1994
Publisher :
University of Edinburgh, 1994.

Abstract

A sample of 35 families with ADPKD from central Scotland, previously typed with two markers from the PKD1 region [3'HVR. However, there is one recombinant with CMM65 (D16S84), and one with 26-6 (D16S125), which localises PKD1 to between these markers. In order to obtain cloned DNA from this genetically defined region of interest, spanning approximately 750 kb of DNA, yeast artificial chromosomes (YACs) were isolated from available libraries.

Subjects

Subjects :
616.042

Details

Language :
English
Database :
British Library EThOS
Publication Type :
Dissertation/ Thesis
Accession number :
edsble.660711
Document Type :
Electronic Thesis or Dissertation

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