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The effect of antidepressant treatment on brain-derived neurotropic factor expression in the rat hippocampus

Authors :
Khundakar, Ahmad Adam
Publication Year :
2004
Publisher :
De Montfort University, 2004.

Abstract

Enhanced BDNF expression has been implicated in the mechanisms of action of antidepressant treatment. Previous findings have shown that chronic antidepressant drug treatment produces a ’bi-phasic effect’ on total BDNF gene expression, i.e. down-regulation at 4h and up-regulation at 24h. The earlier effect is common to acute administration, while the latter is unique to chronic treatment.

Subjects

Subjects :
616.85

Details

Language :
English
Database :
British Library EThOS
Publication Type :
Dissertation/ Thesis
Accession number :
edsble.649953
Document Type :
Electronic Thesis or Dissertation