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The role of vascular endothelial growth factor in the pathogenesis of amyotrophic lateral sclerosis : a transcriptomic approach
- Publication Year :
- 2009
- Publisher :
- University of Sheffield, 2009.
-
Abstract
- Recent evidence suggests that the angiogenic factor, vascular endothelial growth factor (VEGF), has a role in determining the survival of motor neurones. VEGF has a pivotal function in the growth of coordinated vascular and neuronal networks in the developing embryo, and promotes the survival of neurones in vitro. Transgenic (VEGFδ/δ) mice which lack a hypoxia-responsive regulatory element in the VEGF gene express low levels of this neurotrophic factor in neural tissue, and develop adult-onset degeneration of motor neurones, which resembles amyotrophic lateral sclerosis (ALS).
- Subjects :
- 616.839
Lou Gehrig's disease
Subjects
Details
- Language :
- English
- Database :
- British Library EThOS
- Publication Type :
- Dissertation/ Thesis
- Accession number :
- edsble.505480
- Document Type :
- Electronic Thesis or Dissertation