Factors that contribute to the pathogenesis of dengue in adult patients in Vietnam

Dengue fever and dengue hemorrhagic fever (DF /DHF) are caused by the dengue viruses, which belong to family Flaviviridae. DHF incidence has been increasing globally in the last 40 years. Over half the world's population lives in areas potentially at risk for dengue transmission, making dengue the most important human viral disease transmitted by arthropod vectors in terms of morbidity and mortality. Recently, the age distribution of DHF cases in Asia has changed. The number of adults with DHF has increased since the 1990s in Southeast Asian countries including Viet Nam. A series of studies were conducted in the Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam on clinical manifestations, cytokine production in acute infection and T cell responses in adult dengue patients.