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Proton-CAT: a Novel Strategy for Enhanced Proton Therapy

Authors :
Sun, Zhao
He, Zhencen
He, Zhuohang
Wu, Junxiang
Deng, Liyuan
Chen, Ziqi
Jiang, Junkang
Zhu, Hang
Zhang, Shuyu
Hu, Zhimin
Publication Year :
2024

Abstract

We present a nitrogen-targeting-Proton-Carbon-Alpha-Therapy method, abbreviated as Proton-CAT, which partially converts protons into carbon-12 and $\alpha$ particles through nuclear reactions between protons and nitrogen-15. Monte Carlo simulations validated the effectiveness of the Proton-CAT, and the study specifically focused on the distribution of relative energy deposition. The results indicated that the presence of nitrogen-15 enhanced the maximum dose level of protons, resulting in more effective damage confined to tumor cells. Statistical analysis of secondary ions has shown that the Proton-CAT significantly increases the production efficiencies of carbon-12 and $\alpha$ particles. Furthermore, it has been revealed that elevating the nitrogen-15 concentration significantly boosts the dose of carbon and $\alpha$ particles within the tumor region. The present work would contribute to the future development of proton therapy.<br />Comment: 5 pages, 4figures

Details

Database :
arXiv
Publication Type :
Report
Accession number :
edsarx.2402.02760
Document Type :
Working Paper