Measurement of minute volumes of chiral molecules using in-fiber polarimetry

We report an opto-fluidic method that enables to efficiently measure the enantiomeric excess of chiral molecules at low concentration. The approach is to monitor the optical activity induced by a Kagome-lattice hollow-core photonic crystal fiber filled with a sub-ul volume of chiral compound. The technique also allows monitoring the enzymatic racemization of R mandelic acid.