Back to Search
Start Over
Designing Patient-Specific Optimal Neurostimulation Patterns for Seizure Suppression
- Source :
- Neural.Computation 30.5 (2018) 1180-1208
- Publication Year :
- 2018
-
Abstract
- Neurostimulation is a promising therapy for abating epileptic seizures. However, it is extremely difficult to identify optimal stimulation patterns experimentally. In this study human recordings are used to develop a functional 24 neuron network statistical model of hippocampal connectivity and dynamics. Spontaneous seizure-like activity is induced in-silico in this reconstructed neuronal network. The network is then used as a testbed to design and validate a wide range of neurostimulation patterns. Commonly used periodic trains were not able to permanently abate seizures at any frequency. A simulated annealing global optimization algorithm was then used to identify an optimal stimulation pattern which successfully abated 92% of seizures. Finally, in a fully responsive, or "closed-loop" neurostimulation paradigm, the optimal stimulation successfully prevented the network from entering the seizure state. We propose that the framework presented here for algorithmically identifying patient-specific neurostimulation patterns can greatly increase the efficacy of neurostimulation devices for seizures.
- Subjects :
- Quantitative Biology - Neurons and Cognition
Subjects
Details
- Database :
- arXiv
- Journal :
- Neural.Computation 30.5 (2018) 1180-1208
- Publication Type :
- Report
- Accession number :
- edsarx.1801.05116
- Document Type :
- Working Paper
- Full Text :
- https://doi.org/10.1162/neco_a_01075