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Promise and pitfalls of g-ratio estimation with MRI
- Publication Year :
- 2017
-
Abstract
- The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for speed of signal conduction, cellular energetics, and spatial constraints. In vivo imaging of the g-ratio in health and disease would greatly increase our knowledge of the nervous system and our ability to diagnose, monitor, and treat disease. MRI based g-ratio imaging was first conceived in 2011, and expanded to be feasible in full brain with preliminary results in 2013. This manuscript reviews the growing g-ratio imaging literature and speculates on future applications. It details the methodology for imaging the g-ratio with MRI, and describes the known pitfalls and challenges in doing so.<br />Comment: This is the accepted version, accepted by NeuroImage. It contains minor revisions suggested by reviewers
Details
- Database :
- arXiv
- Publication Type :
- Report
- Accession number :
- edsarx.1701.02760
- Document Type :
- Working Paper
- Full Text :
- https://doi.org/10.1016/j.neuroimage.2017.08.038