Back to Search
Start Over
Monte Carlo study of gating and selection in potassium channels
- Source :
- Physical Review E 84, 021920, 2011
- Publication Year :
- 2011
-
Abstract
- The study of selection and gating in potassium channels is a very important issue in modern biology. Indeed such structures are known in all types of cells in all organisms where they play many important functional roles. The mechanism of gating and selection of ionic species is not clearly understood. In this paper we study a model in which gating is obtained via an affinity-switching selectivity filter. We discuss the dependence of selectivity and efficiency on the cytosolic ionic concentration and on the typical pore open state duration. We demonstrate that a simple modification of the way in which the selectivity filter is modeled yields larger channel efficiency.
- Subjects :
- Quantitative Biology - Cell Behavior
Subjects
Details
- Database :
- arXiv
- Journal :
- Physical Review E 84, 021920, 2011
- Publication Type :
- Report
- Accession number :
- edsarx.1108.0356
- Document Type :
- Working Paper
- Full Text :
- https://doi.org/10.1103/PhysRevE.84.021920