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Meta-analysis of epigenome-wide association studies in Alzheimer’s disease highlights 220 differentially methylated loci across cortex
- Authors :
- Smith, Rebecca G.
Pishva, Ehsan
Shireby, Gemma
Smith, Adam R.
Roubroeks, Janou A.Y.
Hannon, Eilis
Wheildon, Gregory
Mastroeni, Diego
Gasparoni, Gilles
Riemenschneider, Matthias
Giese, Armin
Sharp, Andrew J.
Schalkwyk, Leonard
Haroutunian, Vahram
Viechtbauer, Wolfgang
van den Hove, Daniel L.A.
Weedon, Michael
Walter, Jörn
Coleman, Paul D.
Bennett, David A.
Jager, Philip L. De
Mill, Jonathan
Lunnon, Katie - Publication Year :
- 2020
- Publisher :
- Cold Spring Harbor Laboratory, 2020.
-
Abstract
- Epigenome-wide association studies of Alzheimer’s disease have highlighted neuropathology-associated DNA methylation differences, although existing studies have been limited in sample size and utilized different brain regions. Here, we combine data from six methylomic studies of Alzheimer’s disease (N=1,453 unique individuals) to identify differential methylation associated with Braak stage in different brain regions and across cortex. At an experiment-wide significance threshold (P
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.sharebioRxiv..986712f8b5d01767a40045ed593009b4
- Full Text :
- https://doi.org/10.1101/2020.02.28.957894