Potassium-Tertiary Butoxide-Assisted Addition Of Thioglicolic Acid To Chalcone Derivatives Under Solvent-Free Conditions

A series of chalcone derivatives containing thioglicolic acid (4a-j) was prepared by addition of thioglicolic acid to the chalcones (3a-j) in the presence of KOt-Bu under solvent-free conditions. The mechanistic pathway of the reaction can be explained by the Michael-type addition of thioglicolic acid to chalcone derivatives (3a-j).