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Neonatal mortality risk for vulnerable newborn types in 15 countries using 125.5 million nationwide birth outcome records, 2000–2020
- Source :
- Suárez-Idueta, L, Blencowe, H, Okwaraji, Y B, Yargawa, J, Bradley, E, Gordon, A, Flenady, V, Paixao, E S, Barreto, M L, Lisonkova, S, Wen, Q, Velebil, P, Jírová, J, Horváth-Puhó, E, Sørensen, H T, Sakkeus, L, Abuladze, L, Yunis, K A, Al Bizri, A, Barranco, A, Broeders, L, van Dijk, A E, Alyafei, F, Olukade, T O, Razaz, N, Söderling, J, Smith, L K, Draper, E S, Lowry, E, Rowland, N, Wood, R, Monteath, K, Pereyra, I, Pravia, G, Ohuma, E O, Lawn, J E & the National Vulnerable Newborn Mortality Collaborative Group and Vulnerable Newborn Measurement Core Group 2023, ' Neonatal mortality risk for vulnerable newborn types in 15 countries using 125.5 million nationwide birth outcome records, 2000–2020 ', BJOG: An International Journal of Obstetrics and Gynaecology . https://doi.org/10.1111/1471-0528.17506
- Publication Year :
- 2023
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Abstract
- Objective: To compare neonatal mortality associated with six novel vulnerable newborn types in 125.5 million live births across 15 countries, 2000–2020. Design: Population-based, multi-country study. Setting: National data systems in 15 middle- and high-income countries. Methods: We used individual-level data sets identified for the Vulnerable Newborn Measurement Collaboration. We examined the contribution to neonatal mortality of six newborn types combining gestational age (preterm [PT] versus term [T]) and size-for-gestational age (small [SGA], 90th centile) according to INTERGROWTH-21st newborn standards. Newborn babies with PT or SGA were defined as small and T + LGA was considered as large. We calculated risk ratios (RRs) and population attributable risks (PAR%) for the six newborn types. Main outcome measures: Mortality of six newborn types. Results: Of 125.5 million live births analysed, risk ratios were highest among PT + SGA (median 67.2, interquartile range [IQR] 45.6–73.9), PT + AGA (median 34.3, IQR 23.9–37.5) and PT + LGA (median 28.3, IQR 18.4–32.3). At the population level, PT + AGA was the greatest contributor to newborn mortality (median PAR% 53.7, IQR 44.5–54.9). Mortality risk was highest among newborns born before 28 weeks (median RR 279.5, IQR 234.2–388.5) compared with babies born between 37 and 42 completed weeks or with a birthweight less than 1000 g (median RR 282.8, IQR 194.7–342.8) compared with those between 2500 g and 4000 g as a reference group. Conclusion: Preterm newborn types were the most vulnerable, and associated with the highest mortality, particularly with co-existence of preterm and SGA. As PT + AGA is more prevalent, it is responsible for the greatest burden of neonatal deaths at population level.
- Subjects :
- neonatal mortality
preterm birth
size for gestational age
vulnerable newborn
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Suárez-Idueta, L, Blencowe, H, Okwaraji, Y B, Yargawa, J, Bradley, E, Gordon, A, Flenady, V, Paixao, E S, Barreto, M L, Lisonkova, S, Wen, Q, Velebil, P, Jírová, J, Horváth-Puhó, E, Sørensen, H T, Sakkeus, L, Abuladze, L, Yunis, K A, Al Bizri, A, Barranco, A, Broeders, L, van Dijk, A E, Alyafei, F, Olukade, T O, Razaz, N, Söderling, J, Smith, L K, Draper, E S, Lowry, E, Rowland, N, Wood, R, Monteath, K, Pereyra, I, Pravia, G, Ohuma, E O, Lawn, J E & the National Vulnerable Newborn Mortality Collaborative Group and Vulnerable Newborn Measurement Core Group 2023, ' Neonatal mortality risk for vulnerable newborn types in 15 countries using 125.5 million nationwide birth outcome records, 2000–2020 ', BJOG: An International Journal of Obstetrics and Gynaecology . https://doi.org/10.1111/1471-0528.17506
- Accession number :
- edsair.pure.au.......ebcb66c2247bcb8a47d2a97a4aeacb58