Paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2

During the COVID-19 pandemic, the emergence of a new condition with hyperinflammatory shock, resembling Kawasaki disease (KD), was reported in children from Western countries strongly affected by SARS-CoV-2. This syndrome was termed paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection (PIMS-TS). Despite displaying features similar to KD, studies demonstrated a new and more severe disease entity with multiorgan involvement, in particular gastrointestinal symptoms and heart failure, with blood tests consistent with a postinfectious inflammatory condition as summarised in this review.