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Transforming Growth Factor Beta 1 869T/C and 915G/C Polymorphisms and Risk of Autism Spectrum Disorders
- Source :
- Reports of Biochemistry and Molecular Biology, Vol 3, Iss 2, Pp 82-88 (2015)
- Publication Year :
- 2015
- Publisher :
- Varastegan Institute for Medical Sciences, 2015.
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Abstract
- Background: Transforming growth factor-β1 (TGF-β1) has been found to play a crucial role in early central nervous system development. Several studies have illustrated decreased TGF-β1 levels in sera and brains of autistic children. Two point mutations in the TGF-β1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-β1 expression. The aim of the present study was to investigate the correlation of TGF-β1 polymorphisms and their haplotypes with autism. Methods: This study was performed on 39 autistic patients and 35 age- and sex-matched normal controls in an Iranian population, using the sequence specific primed-polymerase chain reaction (PCR-SSP) technique. Patients were divided into mild-to-moderate and severe groups according to the childhood autism rating scale. Results: No significant differences were observed for allele, genotype, or haplotype frequencies between the autistics and controls. Only a slight difference was observed in GC25 between the controls and all children with autism. Conclusion: Thus, these results indicate that the polymorphisms in TGF-β1 gene may not play an important role in the development of autism.
Details
- Language :
- English
- ISSN :
- 23223480
- Volume :
- 3
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Reports of Biochemistry and Molecular Biology
- Accession number :
- edsair.pmid.dedup....fb44bb776fc9668bc211cbf38e8bb003