Back to Search
Start Over
Genetic predisposition to ductal carcinoma in situ of the breast
- Source :
- Breast Cancer Research, 18, Breast Cancer Research : BCR, Breast Cancer Research, 18. BioMed Central Ltd., Petridis, C, Brook, M N, Shah, V, Kohut, K, Gorman, P, Caneppele, M, Levi, D, Papouli, E, Orr, N, Cox, A, Cross, S S, Dos-Santos-Silva, I, Peto, J, Swerdlow, A, Schoemaker, M J, Bolla, M K, Wang, Q, Dennis, J, Michailidou, K, Benitez, J, González-Neira, A, Tessier, D C, Vincent, D, Li, J, Figueroa, J, Kristensen, V, Borresen-Dale, A-L, Soucy, P, Simard, J, Milne, R L, Giles, G G, Margolin, S, Lindblom, A, Brüning, T, Brauch, H, Southey, M C, Hopper, J L, Dörk, T, Bogdanova, N V, Kabisch, M, Hamann, U, Schmutzler, R K, Meindl, A, Brenner, H, Arndt, V, Winqvist, R, Pylkäs, K, Fasching, P A, Beckmann, M W, Lubinski, J, Jakubowska, A, Mulligan, A M, Andrulis, I L, Tollenaar, R A E M, Devilee, P, Le Marchand, L, Haiman, C A, Mannermaa, A, Kosma, V-M, Radice, P, Peterlongo, P, Marme, F, Burwinkel, B, van Deurzen, C H M, Hollestelle, A, Miller, N, Kerin, M J, Lambrechts, D, Floris, G, Wesseling, J, Flyger, H, Bojesen, S E, Yao, S, Ambrosone, C B, Chenevix-Trench, G, Truong, T, Guénel, P, Rudolph, A, Chang-Claude, J, Nevanlinna, H, Blomqvist, C, Czene, K, Brand, J S, Olson, J E, Couch, F J, Dunning, A M, Hall, P, Easton, D F, Pharoah, P D P, Pinder, S E, Schmidt, M K, Tomlinson, I, Roylance, R, García-Closas, M & Sawyer, E J 2016, ' Genetic predisposition to ductal carcinoma in situ of the breast ', Breast Cancer Research, vol. 18, no. 1, pp. 22 . https://doi.org/10.1186/s13058-016-0675-7
- Publication Year :
- 2016
- Publisher :
- BMC, 2016.
-
Abstract
- Background Ductal carcinoma in situ (DCIS) is a non-invasive form of breast cancer. It is often associated with invasive ductal carcinoma (IDC), and is considered to be a non-obligate precursor of IDC. It is not clear to what extent these two forms of cancer share low-risk susceptibility loci, or whether there are differences in the strength of association for shared loci. Methods To identify genetic polymorphisms that predispose to DCIS, we pooled data from 38 studies comprising 5,067 cases of DCIS, 24,584 cases of IDC and 37,467 controls, all genotyped using the iCOGS chip. Results Most (67 %) of the 76 known breast cancer predisposition loci showed an association with DCIS in the same direction as previously reported for invasive breast cancer. Case-only analysis showed no evidence for differences between associations for IDC and DCIS after considering multiple testing. Analysis by estrogen receptor (ER) status confirmed that loci associated with ER positive IDC were also associated with ER positive DCIS. Analysis of DCIS by grade suggested that two independent SNPs at 11q13.3 near CCND1 were specific to low/intermediate grade DCIS (rs75915166, rs554219). These associations with grade remained after adjusting for ER status and were also found in IDC. We found no novel DCIS-specific loci at a genome wide significance level of P
- Subjects :
- 3122 Cancers
Breast Neoplasms
cancer risk
610 Medical sciences Medicine
SDG 3 - Good Health and Well-being
Medizinische Fakultät
Humans
Genetic Predisposition to Disease
Neoplasm Invasiveness
ddc:610
risk-factors
skin and connective tissue diseases
neoplasms
Medicine(all)
grade
variants
Genetic predisposition
Common variants
Carcinoma, Ductal, Breast
Ductal carcinoma in situ
susceptibility loci
Association study
body regions
dcis
Carcinoma, Intraductal, Noninfiltrating
genome-wide association
Carcinoma in Situ
metaanalysis
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14655411 and 1465542X
- Database :
- OpenAIRE
- Journal :
- Breast Cancer Research, 18, Breast Cancer Research : BCR, Breast Cancer Research, 18. BioMed Central Ltd., Petridis, C, Brook, M N, Shah, V, Kohut, K, Gorman, P, Caneppele, M, Levi, D, Papouli, E, Orr, N, Cox, A, Cross, S S, Dos-Santos-Silva, I, Peto, J, Swerdlow, A, Schoemaker, M J, Bolla, M K, Wang, Q, Dennis, J, Michailidou, K, Benitez, J, González-Neira, A, Tessier, D C, Vincent, D, Li, J, Figueroa, J, Kristensen, V, Borresen-Dale, A-L, Soucy, P, Simard, J, Milne, R L, Giles, G G, Margolin, S, Lindblom, A, Brüning, T, Brauch, H, Southey, M C, Hopper, J L, Dörk, T, Bogdanova, N V, Kabisch, M, Hamann, U, Schmutzler, R K, Meindl, A, Brenner, H, Arndt, V, Winqvist, R, Pylkäs, K, Fasching, P A, Beckmann, M W, Lubinski, J, Jakubowska, A, Mulligan, A M, Andrulis, I L, Tollenaar, R A E M, Devilee, P, Le Marchand, L, Haiman, C A, Mannermaa, A, Kosma, V-M, Radice, P, Peterlongo, P, Marme, F, Burwinkel, B, van Deurzen, C H M, Hollestelle, A, Miller, N, Kerin, M J, Lambrechts, D, Floris, G, Wesseling, J, Flyger, H, Bojesen, S E, Yao, S, Ambrosone, C B, Chenevix-Trench, G, Truong, T, Guénel, P, Rudolph, A, Chang-Claude, J, Nevanlinna, H, Blomqvist, C, Czene, K, Brand, J S, Olson, J E, Couch, F J, Dunning, A M, Hall, P, Easton, D F, Pharoah, P D P, Pinder, S E, Schmidt, M K, Tomlinson, I, Roylance, R, García-Closas, M & Sawyer, E J 2016, ' Genetic predisposition to ductal carcinoma in situ of the breast ', Breast Cancer Research, vol. 18, no. 1, pp. 22 . https://doi.org/10.1186/s13058-016-0675-7
- Accession number :
- edsair.pmid.dedup....f6eea26df5b32fcbfc20fd3bc24e85d6