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Time-dependent expression and processing of a hypothetical protein of possible importance for regulation of the Chlamydia pneumoniae developmental cycle
- Source :
- Aalborg University
- Publication Year :
- 2001
-
Abstract
- Chlamydia pneumoniae is an obligate intracellular human pathogen infecting epithelial cells of the upper respiratory tract. It is a Gram-negative bacteria and has a unique biphasic developmental cycle. In this study, we use two-dimensional gel electrophoresis in combination with radioactive labeling to investigate time-dependent expression and processing of C. pneumoniae proteins. We report on (i) the identification of a hypothetical protein which is expressed late in the developmental cycle and subsequently processed; we speculate that this protein may be of importance for the developmental cycle of Chlamydia; (ii) the identification of the major outer membrane protein in three different variants, which may all be present in vivo.
Details
- ISSN :
- 01730835
- Volume :
- 22
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Electrophoresis
- Accession number :
- edsair.pmid.dedup....f03e11f9b126b71b72a857f25d5efa2b