Back to Search
Start Over
Safety and efficacy of artesunate-amodiaquine combined with either methylene blue or primaquine in children with falciparum malaria in Burkina Faso: A randomized controlled trial
- Source :
- PLoS ONE, PLoS ONE, Vol 14, Iss 10, p e0222993 (2019)
- Publication Year :
- 2019
-
Abstract
- Artemisinin resistance is threatening global efforts for malaria control and elimination. Primaquine (PQ) and methylene blue (MB) are gametocytocidal drugs that can be combined with artemisinin-based combination therapy (ACT) to reduce malaria transmission, including resistant strains. Children (6-59 months) with uncomplicated falciparum malaria in Burkina Faso were treated with artesunate-amodiaquine (AS-AQ) and randomized to MB (15 mg/kg/day for 3 days) or PQ (0.25 mg/kg at day 2) with the aim to show non-inferiority of the MB regimen with regard to haematological recovery at day 7 (primary endpoint). MB-AS-AQ could not be shown to be non-inferior to PQ-AS-AQ (mean Hb difference between treatment groups on day 7 was -0.352, 95% CI -0.832-0.128, p = 0.0767), however, haemoglobin recovery following treatment was alike in the two study arms (day 7: mean 0.2±1.4 g/dl vs. 0.5±0.9 g/dl, p = 0.446). Occurrence of adverse events was similar in both groups, except for vomiting, which was more frequent in the MB than in the PQ arm (20/50 vs 7/50, p = 0.003). Adequate clinical and parasitological response was above 95% in both groups, but significantly more asexual parasites were cleared in the MB arm compared to the PQ arm already on day 1 (48/50, 96%, vs 40/50, 80%, p = 0.014). Moreover, P. falciparum gametocyte prevalence and density were lower in the MB arm than in the PQ arm, which reached statistical significance on day 2 (prevalence: 2/50, 4%, vs 15/49, 31%, p
- Subjects :
- Male
Plasmodium
Physiology
Artesunate
Primaquine
Gametocytes
Pathology and Laboratory Medicine
Animal Cells
Medicine and Health Sciences
Malaria, Falciparum
Protozoans
Methylenes
Malarial Parasites
Eukaryota
Drugs
Artemisinins
Chemistry
Treatment Outcome
Child, Preschool
Physical Sciences
Medicine
Drug Therapy, Combination
Female
Artemisinin
Cellular Types
Research Article
Vomiting
Science
Plasmodium falciparum
Antimalarials
Signs and Symptoms
Diagnostic Medicine
parasitic diseases
Burkina Faso
Parasite Groups
Parasitic Diseases
Humans
Pharmacology
Chemical Compounds
Organisms
Amodiaquine
Biology and Life Sciences
Cell Biology
Tropical Diseases
Hydrocarbons
Parasitic Protozoans
Malaria
Methylene Blue
Germ Cells
Parasitology
Physiological Processes
Apicomplexa
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 14
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.pmid.dedup....e9e004f0b058bbba43cedda51a753404