Back to Search
Start Over
An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion
- Source :
- Nature Communications, Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.756. ⟨10.1038/s41467-018-03142-x⟩, 'Nature Communications ', vol: 9, pages: 756-1-756-12 (2018), Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018), Nature Communications, 2018, 9 (1), pp.756. ⟨10.1038/s41467-018-03142-x⟩, Sabbadin, F, Hemsworth, G R, Ciano, L, Henrissat, B, Dupree, P, Tryfona, T, Marques, R D S, Sweeney, S T, Besser, K, Elias, L, Pesante, G, Li, Y, Dowle, A A, Bates, R, Gomez, L D, Simister, R, Davies, G J, Walton, P H, Bruce, N C & McQueen-Mason, S J 2018, ' An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion ', Nature Communications, vol. 9, no. 1, pp. 1-12 . https://doi.org/10.1038/s41467-018-03142-x
- Publication Year :
- 2018
- Publisher :
- Nature Publishing Group, 2018.
-
Abstract
- Thermobia domestica belongs to an ancient group of insects and has a remarkable ability to digest crystalline cellulose without microbial assistance. By investigating the digestive proteome of Thermobia, we have identified over 20 members of an uncharacterized family of lytic polysaccharide monooxygenases (LPMOs). We show that this LPMO family spans across several clades of the Tree of Life, is of ancient origin, and was recruited by early arthropods with possible roles in remodeling endogenous chitin scaffolds during development and metamorphosis. Based on our in-depth characterization of Thermobia’s LPMOs, we propose that diversification of these enzymes toward cellulose digestion might have endowed ancestral insects with an effective biochemical apparatus for biomass degradation, allowing the early colonization of land during the Paleozoic Era. The vital role of LPMOs in modern agricultural pests and disease vectors offers new opportunities to help tackle global challenges in food security and the control of infectious diseases.<br />LPMOs catalyze the oxidative breakdown of polysaccharides, thereby facilitating biomass degradation. By analyzing the digestive proteome of firebrats, the authors here identify a yet uncharacterized LPMO family and provide phylogenetic, structural and biochemical insights into its origin and functions.
- Subjects :
- Models, Molecular
Proteomics
Insecta
Science
Chitin
Genes, Insect
Article
Mixed Function Oxygenases
Evolution, Molecular
Polysaccharides
Animals
Biomass
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM]
lcsh:Science
Cellulose
Arthropods
Phylogeny
food and beverages
Enzymes
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biomolecules [q-bio.BM]
Biodegradation, Environmental
Insect Proteins
lcsh:Q
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Database :
- OpenAIRE
- Journal :
- Nature Communications, Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.756. ⟨10.1038/s41467-018-03142-x⟩, 'Nature Communications ', vol: 9, pages: 756-1-756-12 (2018), Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018), Nature Communications, 2018, 9 (1), pp.756. ⟨10.1038/s41467-018-03142-x⟩, Sabbadin, F, Hemsworth, G R, Ciano, L, Henrissat, B, Dupree, P, Tryfona, T, Marques, R D S, Sweeney, S T, Besser, K, Elias, L, Pesante, G, Li, Y, Dowle, A A, Bates, R, Gomez, L D, Simister, R, Davies, G J, Walton, P H, Bruce, N C & McQueen-Mason, S J 2018, ' An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion ', Nature Communications, vol. 9, no. 1, pp. 1-12 . https://doi.org/10.1038/s41467-018-03142-x
- Accession number :
- edsair.pmid.dedup....e5595ef8bc9c3294074d41b0e65e5a0c