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Primary melanoma of the bladder: a case report and review of the literature
- Source :
- European review for medical and pharmacological sciences. 25(16)
- Publication Year :
- 2021
-
Abstract
- Primary bladder melanomas are rare and aggressive neoplasms. We herein described a new case and performed a review of the literature.We present the case of a 81-year-old woman with a primary mucosal melanoma of the bladder after a history of acral melanoma (KRAS mutated) and lentigo maligna of the forehead. Using PubMed, we found that in literature 38 cases were described.In our patients, during a transurethral resection (TURBT), two bladder lesions were detected. The histologic exam revealed a malignant melanoma, Mib1/ki67: 10-12%, PDL11%. No BRAF, NRAS or KRAS mutations were detected. She subsequently underwent a transurethral revision of the trigone and a partial cystectomy of the dome with bilateral pelvic lymph node dissection. Microscopical findings showed a residual 5 mm non-muscle-invasive melanoma of the bladder, with negativity of the surgical margins and of the 17 pelvic lymph nodes. No adjuvant treatment was proposed. To date the patient is disease-free.Primary bladder melanoma carries a poor prognosis and poses a therapeutic challenge to clinicians who manage patients with this rare condition. In our experience the multidisciplinary approach for the diagnosis and management of this rare cancer is mandatory.
Details
- ISSN :
- 22840729
- Volume :
- 25
- Issue :
- 16
- Database :
- OpenAIRE
- Journal :
- European review for medical and pharmacological sciences
- Accession number :
- edsair.pmid.dedup....dd0eb2a6c2e2342711836f8884d7c01b