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Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs
- Source :
- Alzheimer's Research & Therapy, Alzheimer's research & therapy 8(1), 42 (2016). doi:10.1186/s13195-016-0209-7
- Publication Year :
- 2016
- Publisher :
- BioMed Central, 2016.
-
Abstract
- Background Mild parkinsonian signs (MPS) are common in older people and are associated with an increased risk of different neurodegenerative diseases. This study prospectively evaluates the longitudinal course of cognitive performance in older individuals with MPS. Methods From the TREND study, 480 individuals neurologically healthy at baseline, aged between 50 and 80 years, with complete follow-up data for three assessments within a mean of 43.8 months, were included in this analysis. Participants underwent a detailed cognitive test battery, evaluation of prodromal markers for neurodegenerative diseases and history of vascular diseases at each study visit. In addition, plasma levels of amyloid-beta (Aβ)1–40 and Aβ1–42 were evaluated longitudinally. Results In 52 (11 %) of the 480 participants, MPS could be detected at baseline. These individuals had cognitive deficits significantly more often compared with controls at each time point and their cognitive performance showed a steeper decline during follow-up. In addition, their levels of plasma Aβ1–42 were significantly lower than those of controls, and declined more rapidly over time. Conclusions This longitudinal study shows that MPS are associated with cognitive decline and decrease in plasma Aβ1–42, possibly indicating an ongoing neurodegenerative process. Electronic supplementary material The online version of this article (doi:10.1186/s13195-016-0209-7) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
etiology [Depression]
Cognitive Neuroscience
Clinical Neurology
Sleep, REM
Carotid Intima-Media Thickness
Olfaction Disorders
Apolipoproteins E
Ocular Motility Disorders
Parkinsonian Disorders
complications [Parkinsonian Disorders]
blood [Amyloid beta-Peptides]
Amyloid-beta
Cohort study
Dementia
Longitudinal
Prospective
Neurology
Neurology (clinical)
Humans
ddc:610
Longitudinal Studies
diagnosis [Olfaction Disorders]
diagnosis [Cognition Disorders]
Aged
Aged, 80 and over
Neurologic Examination
Amyloid beta-Peptides
Depression
Research
etiology [Cognition Disorders]
Middle Aged
etiology [Ocular Motility Disorders]
blood [Parkinsonian Disorders]
genetics [Parkinsonian Disorders]
physiology [Sleep, REM]
genetics [Apolipoproteins E]
etiology [Olfaction Disorders]
Female
Cognition Disorders
Subjects
Details
- Language :
- English
- ISSN :
- 17589193
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Alzheimer's Research & Therapy
- Accession number :
- edsair.pmid.dedup....daeababd78cd346a1e7bb962801525d7