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Improving study design for antidepressant effectiveness assessment
- Source :
- International Journal of Methods in Psychiatric Research, International Journal of Methods in Psychiatric Research, Wiley, 2013, 22 (3), pp.217-231. ⟨10.1002/mpr.1391⟩, International Journal of Methods in Psychiatric Research, 2013, 22 (3), pp.217-231. ⟨10.1002/mpr.1391⟩, International Journal of Methods in Psychiatric Research, Wiley, 2013, 22 (3), pp.217-231. 〈10.1002/mpr.1391〉
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- Antidepressants effectiveness in major depressive disorder (MDD) is still questioned because the extrapolation of randomized controlled trial (RCT) results to “real life” settings is problematic. The application of the RCT paradigm in a disorder of this type, where global care plays a central role, raises questions regarding the internal and external validity of this type of study. Outcome measurement, attrition rates, the ability of the double‐blind design to control for expectations, placebo response, the representativeness of trial participants and publication bias are major methodological pitfalls. This review discusses these issues. It is illustrated using original data and proposes some alternatives for assessing antidepressant effectiveness via different approaches. Some are easy to implement, such as ecological measures, qualitative approaches, improvement of analytical strategy and improvement of blinding procedures. Some are sophisticated, involving temporary deception to deal with the confounding effect of expectations, and they raise ethical issues. Others resort to external validity, this being the case in observational studies. But all are necessary to explore antidepressant effectiveness. Copyright © 2013 John Wiley & Sons, Ltd.
- Subjects :
- Depressive Disorder, Major
clinical trials
[SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication
Psychometrics
[ SDV.MHEP.PSM ] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
[ SDV.SP.MED ] Life Sciences [q-bio]/Pharmaceutical sciences/Medication
[SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Reproducibility of Results
effectiveness
methodology
Original Articles
Personality Assessment
Antidepressive Agents
Observational Studies as Topic
Double-Blind Method
[SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication
Research Design
Surveys and Questionnaires
antidepressants
[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health
Outcome Assessment, Health Care
depression
Humans
Randomized Controlled Trials as Topic
Subjects
Details
- Language :
- English
- ISSN :
- 10498931
- Database :
- OpenAIRE
- Journal :
- International Journal of Methods in Psychiatric Research, International Journal of Methods in Psychiatric Research, Wiley, 2013, 22 (3), pp.217-231. ⟨10.1002/mpr.1391⟩, International Journal of Methods in Psychiatric Research, 2013, 22 (3), pp.217-231. ⟨10.1002/mpr.1391⟩, International Journal of Methods in Psychiatric Research, Wiley, 2013, 22 (3), pp.217-231. 〈10.1002/mpr.1391〉
- Accession number :
- edsair.pmid.dedup....d1940ce8cf5215ad27b5268aadf0ac85