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Increased risk for developing gambling disorder under the treatment with pramipexole, ropinirole, and aripiprazole: A nationwide register study in Sweden
- Source :
- PLoS ONE, Vol 16, Iss 6, p e0252516 (2021), PLoS ONE
- Publication Year :
- 2021
- Publisher :
- Public Library of Science (PLoS), 2021.
-
Abstract
- Gambling Disorder (GD) has recently been reclassified from an impulse-control disorder to a behavioural addiction and, as in other addictive disorders, the dopaminergic reward system is involved. According to neuroimaging studies, alterations within the striatal dopaminergic signalling can occur in GD. However, the findings to date are controversial and there has been no agreement yet on how the reward system is affected on a molecular basis. Within the last 20 years, there has been growing evidence for a higher risk to develop GD in response to certain dopaminergic medication. Especially the dopamine agonists pramipexole and ropinirole, and the dopamine modulator aripiprazole seem to increase the likelihood for GD. The goal of this study was to examine the association between a prescription for either of the three pharmaceuticals and a GD diagnosis in a large cross-sectional study of the Swedish population. Compared to patients with any other dopaminergic drug prescription (38.7% with GD), the diagnosis was more common in patients with a dopamine agonist prescription (69.8% with GD), resulting in an odds ratio of 3.2. A similar association was found between aripiprazole prescriptions and GD diagnoses, which were analysed within the subgroup of all patients with schizophrenia or a schizotypal, delusional, or another non-mood psychotic disorder. An aripiprazole prescription increased the likelihood of GD (88.8%) in comparison to patients without an aripiprazole prescription (71.2%) with an odds ratio of 3.4. This study contributes to the increasingly reliable evidence for an association between several dopaminergic drugs and a higher risk for developing GD. Therefore, one future research goal should be a better understanding of the neurobiology in GD to be able to design more selective dopaminergic medication with less severe side effects. Additionally, this knowledge could enable the development of pharmacotherapy in GD and other addictive disorders.
- Subjects :
- Male
Indoles
Epidemiology
Dopamine
Gambling Addiction
Aripiprazole
Social Sciences
Biochemistry
Geographical locations
Pramipexole
Catecholamines
Risk Factors
Medicine and Health Sciences
Psychology
Registries
Amines
Aged, 80 and over
Organic Compounds
Neurochemistry
Neurotransmitters
Middle Aged
Europe
Chemistry
Dopamine Agonists
Physical Sciences
Medicine
Female
Neurochemicals
Research Article
Adult
Biogenic Amines
Science
Addiction
Young Adult
Reward
Mental Health and Psychiatry
Humans
European Union
Aged
Sweden
Behavior
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Hormones
Behavior, Addictive
Cross-Sectional Studies
Behavioral Addiction
Medical Risk Factors
Gambling
Recreation
People and places
Dopaminergics
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.pmid.dedup....d099a972f6ebed6f39f01cf2420548ef