Back to Search
Start Over
Increased plasma free tryptophan levels in human cancer: a tumor related effect?
- Source :
- Scopus-Elsevier, Europe PubMed Central
- Publication Year :
- 1991
-
Abstract
- High free tryptophan (F-TRP) plasma levels are found in cancer patients (CP). F-TRP plasma concentrations are affected by the levels of its carrier, albumin (ALB), and free fatty acids (FFA) competing with TRP for ALB binding sites. The lack of correlation between F-TRP, ALB and FFA in CP suggests a tumor-dependent effect on the rise in F-TRP. To verify this hypothesis, F-TRP, ALB and FFA levels were assayed in 12 lung and 16 breast CP susceptible to radical surgery, before and 15 days after surgical removal of the tumor. F-TRP levels significantly decreased after tumor ablation. Since no correlation was found between F-TRP, ALB and FFA variations, it is conceivable that the tumor itself may be responsible for the high F-TRP levels in CP.
Details
- ISSN :
- 02507005
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Anticancer research
- Accession number :
- edsair.pmid.dedup....d06db7c9c6a512bc186d61745d46b7a9