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Cognitive dysfunction in systemic lupus erythematosus in relation to disease activity and damage
- Source :
- Medicina (Buenos Aires), Vol 77, Iss 4, Pp 257-260 (2017)
- Publication Year :
- 2017
- Publisher :
- Fundación Revista Medicina, 2017.
-
Abstract
- Systemic lupus erythematosus (SLE) is a rheumatic disease, which during its evolution may present neurocognitive dysfunction with fronto-subcortical compromise. However, there is no enough published evidence regarding the relationship between cognitive dysfunction and SLE activity and SLE induced damage. The objective of the study was to analyze this association. We designed an observational cross-sectional study including 84 patients with SLE. We used the SLEDAI index to evaluate activity and the SLICC index to evaluate cumulative damage. We used neuropsychological tests to assess the presence of cognitive symptoms, global cognitive function, verbal and visual memory, visual-construction, semantic verbal fluency, processing speed and working memory. Scores more than 1.5 standard deviations below adjusted normal values were considered as cognitive dysfunction. We observed a statistically significant association between the higher value of SLEDAI and working memory impairment and a higher value of SLICC and viso-construction and semantic verbal fluency impairment. The association observed in SLE patients between disease activity or damage and some cognitive domains may be involving different pathophysiological brain mechanisms of different areas with different degrees of severity and vulnerability.
- Subjects :
- Adult
Male
lcsh:Immunologic diseases. Allergy
SLEDAI
Adolescent
SLICC
lcsh:R
lcsh:Medicine
Middle Aged
Neuropsychological Tests
Severity of Illness Index
lcsh:Infectious and parasitic diseases
Young Adult
Cross-Sectional Studies
systemic lupus erythematosus
Prevalence
Humans
Lupus Erythematosus, Systemic
Cognitive Dysfunction
Female
lcsh:RC109-216
skin and connective tissue diseases
lcsh:RC581-607
Aged
cognitive impairment
Subjects
Details
- Language :
- English
- ISSN :
- 16699106 and 00257680
- Volume :
- 77
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Medicina (Buenos Aires)
- Accession number :
- edsair.pmid.dedup....cd50062cf6c7dc5a032d3e2ba93e20f0