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Original article: role of adjuvant chemotherapy in a perioperative chemotherapy regimen for gastric cancer
- Source :
- BMC Cancer
- Publication Year :
- 2016
-
Abstract
- Background Multimodal treatment strategies – perioperative chemotherapy (CTx) and radical surgery – are currently accepted as treatment standard for locally advanced gastric cancer. However, the role of adjuvant postoperative CTx (postCTx) in addition to neoadjuvant preoperative CTx (preCTx) in this setting remains controversial. Methods Between 4/2006 and 12/2013, 116 patients with locally advanced gastric cancer were treated with preCTx. 72 patients (62 %), in whom complete tumor resection (R0, subtotal/total gastrectomy with D2-lymphadenectomy) was achieved, were divided into two groups, one of which receiving adjuvant therapy (n = 52) and one without (n = 20). These groups were analyzed with regard to survival and exclusion criteria for adjuvant therapy. Results Postoperative complications, as well as their severity grade, did not correlate with fewer postCTx cycles administered (p = n.s.). Long-term survival was shorter in patients receiving postCTx in comparison to patients without postCTx, but did not show statistical significance. In per protocol analysis by excluding two patients with perioperative death, a shorter 3-year survival rate was observed in patients receiving postCTx compared to patients without postCTx (3-year survival: 71.2 % postCTx group vs. 90.0 % non-postCTx group; p = 0.038). Conclusion These results appear contradicting to the anticipated outcome. While speculative, they question the value of post-CTx. Prospectively randomized studies are needed to elucidate the role of postCTx.
- Subjects :
- Adult
Male
Cancer Research
Survival
Antineoplastic Agents
Perioperative Care
Gastrectomy
Stomach Neoplasms
Genetics
Chemotherapy
Humans
Adjuvant
Aged
Aged, 80 and over
ddc:616
Middle Aged
Survival Analysis
Treatment Outcome
Oncology
Chemotherapy, Adjuvant
Multimodal
Lymph Node Excision
Female
Risk factor
Neoadjuvant
Gastric cancer
Complication
Research Article
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.pmid.dedup....cc68a77a99d2745fed81cbb9652df26a