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Inhibition of MAO by substituted tryptamine analogues

Authors :
Balsa D
Fernandez-Alvarez E
Kf, Tipton
Mercedes UNZETA
Source :
Europe PubMed Central

Abstract

Three different acetylenic analogues of tryptamine, in which the side chain is attached at the 2 position of the heterocyclic ring, were studied as inhibitors of MAO-A and MAO-B. IC50 values were determined after 30 min preincubation of the enzyme and inhibitor, at 37 degrees C before assay. Irreversibility and time-dependence of the inhibition were also established in each case. The kinetic parameters defining non-covalent complex formation and covalent adduct formation were calculated for the mechanism-based inhibition of both MAO-A and MAO-B by these compounds.

Details

Database :
OpenAIRE
Journal :
Europe PubMed Central
Accession number :
edsair.pmid.dedup....c903a79b2724374cf377bb4e34b9a101