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Variable roles of interleukin-17F in different cancers
- Source :
- BMC Cancer, BMC Cancer, Vol 22, Iss 1, Pp 1-14 (2022)
- Publication Year :
- 2022
- Publisher :
- Springer Nature, 2022.
-
Abstract
- Background: Interleukin (IL)-17 family is a group of six cytokines that plays a central role in inflammatory processes and participates in cancer progression. Interleukin-17A has been shown to have mainly a protumorigenic role, but the other members of the IL-17 family, including IL-17F, have received less attention. Methods: We applied systematic review guidelines to study the role of IL-17F, protein and mRNA expression, polymorphisms, and functions, in cancer. We carried out a systematic search in PubMed, Ovid Medline, Scopus, and Cochrane libraries, yielding 79 articles that met the inclusion criteria. Results: The findings indicated that IL-17F has both anti- and protumorigenic roles, which depend on cancer type and the molecular form and location of IL-17F. As an example, the presence of IL-17F protein in tumor tissue and patient serum has a protective role in oral and pancreatic cancers, whereas it is protumorigenic in prostate and bladder cancers. These effects are proposed to be based on multiple mechanisms, such as inhibition of angiogenesis, vasculogenic mimicry and cancer cell proliferation, migration and invasion, and aggravating the inflammatory process. No solid evidence emerged for the correlation between IL-17F polymorphisms and cancer incidence or patients’ prognosis. Conclusions: IL-17F is a multifaceted cytokine. There is a clear demand for more well-designed studies of IL-17F to elucidate its molecular mechanisms in different types of cancer. The studies presented in this article examined a variety of different designs, study populations and primary/secondary outcomes, which unfortunately reduces the value of direct interstudy comparisons.
- Subjects :
- CERVICAL-CANCER
AND-17F GENES
Carcinogenesis
3122 Cancers
BLADDER-CANCER
Prognostic
GENE POLYMORPHISMS
Polymorphism, Single Nucleotide
COLORECTAL-CANCER
Mice
IL-17F
Cell Line, Tumor
Neoplasms
Biomarkers, Tumor
Animals
Humans
cancer
Lymphocytes
Polymorphism
RC254-282
RISK
Research
Interleukin-17
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
CELL CARCINOMA
SERUM-LEVELS
Prognosis
SINGLE NUCLEOTIDE POLYMORPHISMS
Systematic review
GASTRIC-CANCER
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- BMC Cancer, BMC Cancer, Vol 22, Iss 1, Pp 1-14 (2022)
- Accession number :
- edsair.pmid.dedup....c6c3be12fdf564fe0b77a401971a1bc3