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Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways
- Source :
- Howard, D M, Adams, M J, Shirali, M, Clarke, T-K, Marioni, R E, Davies, G, Coleman, J R I, Alloza, C, Shen, X, Barbu, M C, Wigmore, E M, Gibson, J, Hagenaars, S P, Lewis, C M, Ward, J, Smith, D J, Sullivan, P F, Haley, C S, Breen, G & Deary, I J & McIntosh, A M 2018, ' Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways ', Nature Communications, vol. 9, no. 1, 1470, pp. 1-10 . https://doi.org/10.1038/s41467-018-03819-3, Nature Communications, Howard, D M, Adams, M J, Shirali, M, Clarke, T-K, Marioni, R E, Davies, G, Coleman, J R I, Alloza, C, Shen, X, Barbu, M C, Wigmore, E M, Gibson, J, Hagenaars, S P, Lewis, C M, Ward, J, Smith, D J, Sullivan, P F, Haley, C S, Breen, G, Deary, I J & McIntosh, A M 2018, ' Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways ', Nature Communications, vol. 9, no. 1, 1470 . https://doi.org/10.1038/s41467-018-03819-3, Howard, D M, Adams, M J, Shirali, M, Clarke, T K, Marioni, R E, Davies, G, Coleman, J R I, Alloza, C, Shen, X, Barbu, M C, Wigmore, E M, Gibson, J, Hagenaars, S P, Lewis, C M, Ward, J, Smith, D J, Sullivan, P F, Haley, C S, Breen, G, Deary, I J & McIntosh, A M 2018, ' Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways ', Nature Communications, vol. 9, no. 1 . https://doi.org/10.1038/s41467-018-03819-3
- Publication Year :
- 2018
-
Abstract
- Depression is a polygenic trait that causes extensive periods of disability. Previous genetic studies have identified common risk variants which have progressively increased in number with increasing sample sizes of the respective studies. Here, we conduct a genome-wide association study in 322,580 UK Biobank participants for three depression-related phenotypes: broad depression, probable major depressive disorder (MDD), and International Classification of Diseases (ICD, version 9 or 10)-coded MDD. We identify 17 independent loci that are significantly associated (P<br />The UK Biobank provides data for three depression-related phenotypes. Here, Howard et al. perform a genome-association study for broad depression, probable major depressive disorder (MDD) and hospital record-coded MDD in up to 322,580 UK Biobank participants which highlights excitatory synaptic pathways.
- Subjects :
- Synapses/genetics
Depression/genetics
Biomarkers/metabolism
Article
Linkage Disequilibrium
United Kingdom
Cohort Studies
Phenotype
Gene Expression Regulation
Genetic Loci
International Classification of Diseases
Mechanotransduction, Cellular/genetics
Humans
Nerve Tissue Proteins/genetics
Genetic Predisposition to Disease
Synaptic Transmission/genetics
Depressive Disorder, Major/genetics
Biological Specimen Banks
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Howard, D M, Adams, M J, Shirali, M, Clarke, T-K, Marioni, R E, Davies, G, Coleman, J R I, Alloza, C, Shen, X, Barbu, M C, Wigmore, E M, Gibson, J, Hagenaars, S P, Lewis, C M, Ward, J, Smith, D J, Sullivan, P F, Haley, C S, Breen, G & Deary, I J & McIntosh, A M 2018, ' Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways ', Nature Communications, vol. 9, no. 1, 1470, pp. 1-10 . https://doi.org/10.1038/s41467-018-03819-3, Nature Communications, Howard, D M, Adams, M J, Shirali, M, Clarke, T-K, Marioni, R E, Davies, G, Coleman, J R I, Alloza, C, Shen, X, Barbu, M C, Wigmore, E M, Gibson, J, Hagenaars, S P, Lewis, C M, Ward, J, Smith, D J, Sullivan, P F, Haley, C S, Breen, G, Deary, I J & McIntosh, A M 2018, ' Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways ', Nature Communications, vol. 9, no. 1, 1470 . https://doi.org/10.1038/s41467-018-03819-3, Howard, D M, Adams, M J, Shirali, M, Clarke, T K, Marioni, R E, Davies, G, Coleman, J R I, Alloza, C, Shen, X, Barbu, M C, Wigmore, E M, Gibson, J, Hagenaars, S P, Lewis, C M, Ward, J, Smith, D J, Sullivan, P F, Haley, C S, Breen, G, Deary, I J & McIntosh, A M 2018, ' Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways ', Nature Communications, vol. 9, no. 1 . https://doi.org/10.1038/s41467-018-03819-3
- Accession number :
- edsair.pmid.dedup....be496f43b0c193605e6dce29679b944b
- Full Text :
- https://doi.org/10.1038/s41467-018-03819-3