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Predictive and prognostic significance of neuron-specific enolase (NSE) in non-small cell lung cancer

Authors :
Tiseo, M.
Ardizzoni, A.
Cafferata, M. A.
Loprevite, M.
Chiaramondia, M.
Filiberti, R.
Marroni, P.
Francesco Grossi
Paganuzzi, M.
Tiseo M
Ardizzoni A
Cafferata MA
Loprevite M
Chiaramondia M
Filiberti R
Marroni P
Gross F
Paganuzzi M
Source :
Scopus-Elsevier, Europe PubMed Central
Publication Year :
2008

Abstract

Background: The Predictive and prognostic role of neuron-specific enolase (NSE) in non-small cell lung cancer (NSCLC) is still under debate. Patients and Methods: To study these aspects, serum NSE was prospectively measured at baseline of first-line chemotherapy treatment and tested for correlation with clinical outcome in 129 advanced NSCLC patients. Results: An objective response was achieved in 2 7 out of 65 (41.5%) patients with NSE = 8.6 ng/ml (p = 0.05). Logistic analysis confirmed the positive association between objective response and NSE values >= 8.6 ng/ml (odds ratio=1.69; 95% confidence interval: 1.09-2.63; p=0.02). Overall median survival was 10.8 months. A statistically significant prognostic effect on survival was found for performance status, stage and response to treatment, but not for baseline NSE value. Conclusion: Based on these data, baseline circulating tumor NSE levels appear to have a weak predictive role, but not a prognostic significance in patients with advanced NSCLC submitted to standard chemotherapy.

Details

Language :
English
Database :
OpenAIRE
Journal :
Scopus-Elsevier, Europe PubMed Central
Accession number :
edsair.pmid.dedup....b0762bb92a4f10ce8d0fd8d00934ed2f