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Nonfasting Glucose, Ischemic Heart Disease, and Myocardial Infarction A Mendelian Randomization Study
- Source :
- Journal of the American College of Cardiology. (25):2356-2365
- Publisher :
- American College of Cardiology Foundation. Published by Elsevier Inc.
-
Abstract
- OBJECTIVES: The purpose of this study was to test whether elevated nonfasting glucose levels associate with and cause ischemic heart disease (IHD) and myocardial infarction (MI). BACKGROUND: Elevated fasting plasma glucose levels associate with increased risk of IHD, but whether this is also true for nonfasting levels and whether this is a causal relationship is unknown. METHODS: Using a Mendelian randomization approach, we studied 80,522 persons from Copenhagen, Denmark. Of those, IHD developed in 14,155, and MI developed in 6,257. Subjects were genotyped for variants in GCK (rs4607517), G6PC2 (rs560887), ADCY5 (rs11708067), DGKB (rs2191349), and ADRA2A (rs10885122) associated with elevated fasting glucose levels in genome-wide association studies. RESULTS: Risk of IHD and MI increased stepwise with increasing nonfasting glucose levels. The hazard ratio for IHD in subjects with nonfasting glucose levels ≥11 mmol/l (≥198 mg/dl) versus
- Subjects :
- Adult
Blood Glucose
Male
Genotype
Denmark
Myocardial Infarction
Myocardial Ischemia
Kaplan-Meier Estimate
plasma glucose
Risk Assessment
Article
Body Mass Index
Risk Factors
cardiovascular disease
Odds Ratio
Humans
cardiovascular diseases
Alleles
Aged
Proportional Hazards Models
Polymorphism, Genetic
Cholesterol, HDL
nonfasting
Mendelian Randomization Analysis
Middle Aged
post-prandial
Hypertension
diabetes mellitus
Female
epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 07351097
- Issue :
- 25
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.pmid.dedup....add279e10b6a7326c9c54ce9e2abcc5e
- Full Text :
- https://doi.org/10.1016/j.jacc.2012.02.043