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Beta-catenin and surviving expression in keratocystic odontogenic tumor (KCOT). A comparative immunohistochemical study in primary, recurrent and nevoid basal cell carcinoma syndrome (NBCCS)-associated lesions
- Source :
- Scopus-Elsevier, Publons, DIGITUM. Depósito Digital Institucional de la Universidad de Murcia, instname
- Publication Year :
- 2013
- Publisher :
- F HERNANDEZ, PLAZA FUENSANTA 2-7 C, 30008 MURCIA, SPAIN, 2013.
-
Abstract
- Aim: To determine the epithelial expression of ß-catenin and survivin in sporadic (primary, and recurrent) and nevoid basal cell carcinoma syndrome (NBCCS) keratocystic odontogenic tumour (KCOT) in order to assess activation of the ß-catenin pathway and evidence of apoptotic inhibition, processes that may contribute to the known differences in their biological behaviour. Materials and Methods: Sections from 40 cases of KCOT (19 sporadic/primary; 9 sporadic/recurrent and 12 NBCCS-associated) were immunohistochemically stained for ß-catenin and survivin. The extent and intensity of immunoreactivity within the lining epithelium was assessed, using semi-quantitative scales, independently by two pathologists who were blinded to the clinical-pathological data. Data were analysed using Kruskal-Wallis test and, for pair-wise comparisons, Mann-Whitney test with Bonferroni correction. Results: All cystic epithelial linings stained for ß- catenin and survivin but there were differences in the pattern and intensity of staining among KCOT types. Sporadic primary KCOT showed weaker staining for ß- catenin (P=0.0003) and survivin (P
- Subjects :
- Adult
Male
Histology
Adolescent
Survivin
6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU]
Settore MED/50 - Scienze Tecniche Mediche Applicate
Apoptosis
Odontogenic Tumors
ß-catenin
NBCCS
Inhibitor of Apoptosis Proteins
Settore MED/29 - Chirurgia Maxillofacciale
Young Adult
Recurrence
Settore MED/28 - Malattie Odontostomatologiche
Humans
beta Catenin
Cell Cycle
NBCCS, ß-catenin, Survivin, KCOT
Basal Cell Nevus Syndrome
Middle Aged
Immunohistochemistry
Gene Expression Regulation, Neoplastic
stomatognathic diseases
KCOT
2734
Keratins
Female
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Scopus-Elsevier, Publons, DIGITUM. Depósito Digital Institucional de la Universidad de Murcia, instname
- Accession number :
- edsair.pmid.dedup....a9d25da590c0dc84323d91171b16a92d