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Association of interleukin 8 and myocardial recovery in patients with ST-elevation myocardial infarction complicated by acute heart failure
- Source :
- PLoS ONE, Vol 9, Iss 11, p e112359 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Background No data from controlled trials exists regarding the inflammatory response in patients with de novo heart failure (HF) complicating ST-elevation myocardial infarction (STEMI) and a possible role in the recovery of contractile function. We therefore explored the time course and possible associations between levels of inflammatory markers and recovery of impaired left ventricular function as well as levosimendan treatment in STEMI patients in a substudy of the LEvosimendan in Acute heart Failure following myocardial infarction (LEAF) trial. Methods A total of 61 patients developing HF within 48 hours after a primary PCI-treated STEMI were randomised double-blind to a 25 hours infusion of levosimendan or placebo. Levels of IL-6, CRP, sIL-6R, sgp130, MCP-1, IL-8, MMP-9, sICAM-1, sVCAM-1 and TNF-α were measured at inclusion (median 22 h, interquartile range (IQR) 14, 29 after PCI), on day 1, day 2, day 5 and 6 weeks. Improvement in left ventricular function was evaluated as change in wall motion score index (WMSI) by echocardiography. Results Only circulating levels of IL-8 at inclusion were associated with change in WMSI from baseline to 6 weeks, r = ÷0.41 (p = 0.002). No association, however, was found between IL-8 and WMSI at inclusion or peak troponin T. Furthermore, there was a significant difference in change in WMSI from inclusion to 6 weeks between patients with IL-8 levels below, compared to above median value, ÷0.44 (IQR÷0.57, ÷0.19) vs. ÷0.07 (IQR÷0.27, 0.07), respectively (p
- Subjects :
- Male
Cardiotonic Agents
Morpholines
Immunology
Cardiology
Myocardial Infarction
Vascular Cell Adhesion Molecule-1
lcsh:Medicine
Ventricular Function, Left
Medicine and Health Sciences
Humans
cardiovascular diseases
lcsh:Science
Immune Response
Simendan
Aged
Inflammation
Heart Failure
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukin-8
lcsh:R
Hydrazones
Biology and Life Sciences
Recovery of Function
Middle Aged
Intercellular Adhesion Molecule-1
Myocardial Contraction
Receptors, Interleukin-6
Pyridazines
C-Reactive Protein
Matrix Metalloproteinase 9
Female
lcsh:Q
Biomarkers
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.pmid.dedup....a530f5df3bd5aa1f0cd7f1ebabca9bc7