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Vascular risk factors are associated with a decline in resting-state functional connectivity in cognitively unimpaired individuals at risk for Alzheimer's disease: Vascular risk factors and functional connectivity changes
- Source :
- NeuroImage 231, 117832-(2021). doi:10.1016/j.neuroimage.2021.117832
- Publication Year :
- 2021
- Publisher :
- Academic Press, 2021.
-
Abstract
- Resting-state functional connectivity is suggested to be cross-sectionally associated with both vascular burden and Alzheimer's disease (AD) pathology. However, evidence is lacking regarding longitudinal changes in functional connectivity. This study includes 247 cognitively unimpaired individuals with a family history of sporadic AD (185 women/ 62 men; mean [SD] age of 63 [5.3] years). Plasma total-, HDL-, and LDL-cholesterol and systolic and diastolic blood pressure were measured at baseline. Global (whole-brain) brain functional connectivity and connectivity from canonical functional networks were computed from resting-state functional MRI obtained at baseline and ~3.5 years of annual follow-ups, using a predefined functional parcellation. A subsample underwent Aβ- and tau-PET (n=91). Linear mixed-effects models demonstrated that global functional connectivity increased over time across the entire sample. In contrast, higher total-cholesterol and LDL-cholesterol levels were associated with greater reduction of functional connectivity in the default-mode network over time. In addition, higher diastolic blood pressure was associated with global functional connectivity reduction. The associations were similar when the analyses were repeated using two other functional brain parcellations. Aβ and tau deposition in the brain were not associated with changes in functional connectivity over time in the subsample. These findings provide evidence that vascular burden is associated with a decrease in functional connectivity over time in older adults with elevated risk for AD. Future studies are needed to determine if the impact of vascular risk factors on functional brain changes precede the impact of AD pathology on functional brain changes.
- Subjects :
- Male
Longitudinal resting-state functional connectivity
Rest
trends [Magnetic Resonance Imaging]
physiopathology [Brain]
physiopathology [Alzheimer Disease]
diagnostic imaging [Vascular Diseases]
physiopathology [Vascular Diseases]
Cognition
methods [Magnetic Resonance Imaging]
Alzheimer Disease
Risk Factors
physiopathology [Nerve Net]
Humans
Vascular Diseases
ddc:610
Longitudinal Studies
tau
diagnostic imaging [Brain]
Aged
Aged, 80 and over
diagnostic imaging [Nerve Net]
physiology [Cognition]
Brain
Middle Aged
Magnetic Resonance Imaging
physiology [Rest]
Default-mode network
Vascular risk factors
Global functional connectivity
Female
Nerve Net
β-Amyloid
diagnostic imaging [Alzheimer Disease]
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- NeuroImage 231, 117832-(2021). doi:10.1016/j.neuroimage.2021.117832
- Accession number :
- edsair.pmid.dedup....9d4a3127a7d2b60381de2f2e7531b993