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Prognostic factors in phyllodes tumours of the breast: retrospective study on 166 consecutive cases

Authors :
Maria Vittoria Dieci
Valentina Guarneri
Angelo Paolo Dei Tos
PierFranco Conte
Elisabetta Di Liso
Michele Bottosso
Marcello Lo Mele
Vassilena Tsvetkova
Federica Miglietta
Cristina Falci
Giovanni Faggioni
Giulia Tasca
Carlo Alberto Giorgi
Tommaso Giarratano
Eleonora Mioranza
Silvia Michieletto
Tania Saibene
Source :
ESMO Open, ESMO Open, Vol 5, Iss 5 (2020)
Publication Year :
2020

Abstract

Background Phyllodes tumours (PTs) are rare fibroepithelial tumours accounting for 5 cm vs T≤2 cm). Higher tumour-infiltrating lymphocytes (TILs) were associated with borderline and malignant PT (p=0.023); TILs were not associated with phyllodes-related relapse-free survival (HR 0.58, p=0.361 for TILs>2% vs≤2%). Overall, four patients died because of PT: three patients with malignant and one with borderline PT.Conclusions Patients with malignant PT had increased rates of phyllodes-related relapse and phyllodes-related death. Cellular atypia and heterologous differentiation were poor prognostic factors in the entire cohort; large tumour size was associated with an increased risk of phyllodes-related relapse in benign PT.

Details

ISSN :
20597029
Volume :
5
Issue :
5
Database :
OpenAIRE
Journal :
ESMO open
Accession number :
edsair.pmid.dedup....90f4b3a3934cb3a020748b995fdd10f7