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Prognostic factors in phyllodes tumours of the breast: retrospective study on 166 consecutive cases
- Source :
- ESMO Open, ESMO Open, Vol 5, Iss 5 (2020)
- Publication Year :
- 2020
-
Abstract
- Background Phyllodes tumours (PTs) are rare fibroepithelial tumours accounting for 5 cm vs T≤2 cm). Higher tumour-infiltrating lymphocytes (TILs) were associated with borderline and malignant PT (p=0.023); TILs were not associated with phyllodes-related relapse-free survival (HR 0.58, p=0.361 for TILs>2% vs≤2%). Overall, four patients died because of PT: three patients with malignant and one with borderline PT.Conclusions Patients with malignant PT had increased rates of phyllodes-related relapse and phyllodes-related death. Cellular atypia and heterologous differentiation were poor prognostic factors in the entire cohort; large tumour size was associated with an increased risk of phyllodes-related relapse in benign PT.
- Subjects :
- histological classification
Breast Neoplasms
phyllodes-related death
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
lcsh:RC254-282
Phyllodes Tumor
phyllodes-related recurrence
Humans
Female
phyllodes tumours
Neoplasm Recurrence, Local
breast
Mastectomy
Retrospective Studies
Original Research
Subjects
Details
- ISSN :
- 20597029
- Volume :
- 5
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- ESMO open
- Accession number :
- edsair.pmid.dedup....90f4b3a3934cb3a020748b995fdd10f7