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Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences
- Source :
- Translational Psychiatry, Translational Psychiatry, Vol 9, Iss 1, Pp 1-12 (2019), Roberts, S, Suderman, M, Zammit, S, Watkins, S H, Hannon, E, Mill, J, Relton, C, Arseneault, L, Wong, C C Y & Fisher, H L 2019, ' Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences ', Translational Psychiatry, vol. 9, no. 1, 69 . https://doi.org/10.1038/s41398-019-0407-8, Roberts, S L, Suderman, M, Zammit, S, Watkins, S H, Hannon, E, Mill, J, Relton, C, Arseneault, L, Wong, C C Y & Fisher, H 2019, ' Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences ', Translational psychiatry, vol. 9, 69, pp. 1-12 . https://doi.org/10.1038/s41398-019-0407-8
- Publication Year :
- 2019
-
Abstract
- Childhood psychotic experiences (PEs), such as seeing or hearing things that others do not, or extreme paranoia, are relatively common with around 1 in 20 children reporting them at age 12. Childhood PEs are often distressing and can be predictive of schizophrenia, other psychiatric disorders, and suicide attempts in adulthood, particularly if they persist during adolescence. Previous research has demonstrated that methylomic signatures in blood could be potential biomarkers of psychotic phenomena. This study explores the association between DNA methylation (DNAm) and the emergence, persistence, and remission of PEs in childhood and adolescence. DNAm profiles were obtained from the ALSPAC cohort at birth, age 7, and age 15/17 (n = 901). PEs were assessed through interviews with participants at ages 12 and 18. We identified PE-associated probes (p
Details
- Language :
- English
- ISSN :
- 21583188
- Database :
- OpenAIRE
- Journal :
- Translational Psychiatry, Translational Psychiatry, Vol 9, Iss 1, Pp 1-12 (2019), Roberts, S, Suderman, M, Zammit, S, Watkins, S H, Hannon, E, Mill, J, Relton, C, Arseneault, L, Wong, C C Y & Fisher, H L 2019, ' Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences ', Translational Psychiatry, vol. 9, no. 1, 69 . https://doi.org/10.1038/s41398-019-0407-8, Roberts, S L, Suderman, M, Zammit, S, Watkins, S H, Hannon, E, Mill, J, Relton, C, Arseneault, L, Wong, C C Y & Fisher, H 2019, ' Longitudinal investigation of DNA methylation changes preceding adolescent psychotic experiences ', Translational psychiatry, vol. 9, 69, pp. 1-12 . https://doi.org/10.1038/s41398-019-0407-8
- Accession number :
- edsair.pmid.dedup....8d4fea92b58f3fe61203ff6b16ba5982