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Ethanol Extract of Leaves of Cassia siamea Lam Protects against Diabetes-Induced Insulin Resistance, Hepatic, and Endothelial Dysfunctions in ob/ob Mice
- Source :
- Oxidative Medicine and Cellular Longevity, Oxidative Medicine and Cellular Longevity, Hindawi, 2019, 2019, pp.6560498. ⟨10.1155/2019/6560498⟩, Oxidative Medicine and Cellular Longevity, Vol 2019 (2019), Oxidative Medicine and Cellular Longevity, 2019, 2019, pp.6560498. ⟨10.1155/2019/6560498⟩
- Publication Year :
- 2019
- Publisher :
- Hindawi, 2019.
-
Abstract
- International audience; Despite long traditional utilization and some reports on the antihyperglycemic and antihyperlipidemic action of Cassia siamea, the mechanisms involved have not been investigated yet. Thus, the objective of the present study was to investigate whether and how oral administration of the ethanolic extract of Cassia siamea Lam leaves (LECS) improves glucose and insulin homoeostasis, liver damage, and endothelial dysfunction in an experimental model of type 2 diabetes, the leptin-deficient ob/ob mice. Oxidative stress and protein expression of insulin-dependent and insulin -independent signaling pathways were studied. Obese ( ob/ob) vs. control (ob/+) mice were treated daily with intragastric administration of either vehicle or LECS (200 mg/kg, per day) for 4 weeks. Fasting blood glucose, body weight, food intake, glucose and insulin tolerance, oxidative stress, and liver damage as well as vascular complications with respect to endothelial dysfunction were examined. Administration of LECS in obese mice significantly reduced blood glucose and insulin levels, improved glucose tolerance and insulin sensitivity, and restored the increase of circulating AST and ALT without modification of body weight and food intake. These effects were associated with increased activity of both insulin and AMPK pathways in the liver and skeletal muscles. Of particular interest, administration of LECS in obese mice completely prevented the endothelial dysfunction resulting from an increased NO· and decreased reactive oxygen species (ROS) production in the aorta. Altogether, oral administration of LECS remarkably attenuates features of type 2 diabetes on glucose, hepatic inflammation, insulin resistance, endothelial function, and vascular oxidative stress, being as most of these effects are related to insulin-dependent and insulin-independent mechanisms. Therefore, this study points for the therapeutic potential of Cassia siamea in correcting both metabolic and vascular alterations linked to type 2 diabetes.
- Subjects :
- Male
Ethanol
[SDV.BA] Life Sciences [q-bio]/Animal biology
Article Subject
Plant Extracts
lcsh:Cytology
[SDV]Life Sciences [q-bio]
[SDV.BA]Life Sciences [q-bio]/Animal biology
Cassia
[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences
Plant Leaves
[SDV] Life Sciences [q-bio]
[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences
Mice
Diabetes Mellitus, Type 2
Animals
Female
Insulin Resistance
lcsh:QH573-671
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19420900 and 19420994
- Database :
- OpenAIRE
- Journal :
- Oxidative Medicine and Cellular Longevity
- Accession number :
- edsair.pmid.dedup....8aa43d58daf9e1026a8ae2a50c39564b
- Full Text :
- https://doi.org/10.1155/2019/6560498