Analytical profile of zolpidem

The paper present an analytical profile of Zolpidem. The applications of chromatographic methods (HPLC and HPTLC) and non-aqueous titrimetry in the analysis of this drug are described. Partition coefficients at pH 2.0 and 7.4 and absorptivity values have been determined. Reversed phase HPLC and HPTLC systems have been successfully performed utilizing methanol/water mixtures as eluent and octadecylsilane as stationary phase. Acidimetric and alkalimetric methods in non aqueous titrimetry have been applied for quantitative analysis. The suggested procedures are proposed as an effective tool for quality control on pure compound and pharmaceutical formulations.